Important Facts

This medicine can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

Seek emergency medical help if you have symptoms of heart or circulation problems, such as:

• chest pain
• weakness
• shortness of breath
• slurred speech
• problems with vision or balance

This medicine can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking Daypro. Older adults may have an even greater risk of these serious gastrointestinal side effects.

Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes:

• black
• bloody, or tarry stools
• coughing up blood
• vomit that looks like coffee grounds

How To Take Daypro (oxaprozin)

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. The maximum amount of Daypro for adults is 1200 milligrams (mg) per day. Know the amount of Daypro in the specific product you are taking.

If you take Daypro for a long period of time, your doctor may want to check you on a regular basis to make sure this medication is not causing harmful effects. Do not miss any scheduled visits to your doctor.

Store Daypro at room temperature, away from moisture, heat, and light.

If You Forget A Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a Daypro overdose may include:

• nausea
• vomiting
• dizziness
• drowsiness
• black or bloody stools
• coughing up blood
• fever
• urinating less than usual or not at all
• shallow breathing
• fainting
• coma

Taking an NSAID can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use an NSAID. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

NSAIDs can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects.

Do not use this medication if you are allergic to Daypro, or to aspirin or other NSAIDs.

Before taking Daypro, tell your doctor if you are allergic to any drugs, or if you have:

• a history of heart attack, stroke, or blood clot
• heart disease, congestive heart failure, high blood pressure
• a history of stomach ulcers or bleeding, bowel problems, diverticulosis
• liver or kidney disease
• asthma
• polyps in your nose
• if you smoke

If you have any of these conditions, you may not be able to use Daypro, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking Daypro during the last 3 months of pregnancy may result in birth defects. Do not take Daypro during pregnancy unless your doctor has told you to. Daypro can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medicine to a child younger than 6 years old without the advice of a doctor.

Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction:

• hives
• difficulty breathing
• swelling of your face, lips, tongue or throat

Stop taking Daypro and seek medical attention or call your doctor at once if you have any of these SERIOUS side effects:

• chest pain
• weakness, shortness of breath
• slurred speech
• problems with vision or balance
• black, bloody, or tarry stools
• coughing up blood or vomit that looks like coffee grounds
• confusion, tremors or shaking
• urinating less than usual or not at all
• nausea, stomach pain, low fever
• loss of appetite
• dark urine, clay-colored stools
• jaundice (yellowing of the skin or eyes)
• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash
• bruising, severe tingling, numbness, pain, muscle weakness

Keep taking Daypro and talk to your doctor if you have any of these less serious side effects:

• upset stomach, mild heartburn or stomach pain
• diarrhea, constipation
• bloating, gas
• dizziness, headache, nervousness
• skin itching or rash
• blurred vision
• dry mouth
• increased sweating, runny nose
• blurred vision
• ringing in your ears

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

Before taking Daypro®, tell your doctor if you are using any of the following drugs:

• cyclosporine (Gengraf®, Neoral®, Sandimmune®)
• lithium (Eskalith®, Lithobid®)
• methotrexate (Rheumatrex®, Trexall®)
• probenecid (Benemid®)
• steroids (prednisone and others)
• a blood thinner such as warfarin (Coumadin®)

• an anti-platelet medication such as:
• clopidogrel (Plavix®)
• dipyridamole (Persantine®)
• ticlopidine (Ticlid®), and others

• aspirin or NSAIDs (non-steroidal anti-inflammatory drugs) such as:
• diclofenac (Voltaren®)
• etodolac (Lodine®)
• fenoprofen (Nalfon®)
• flurbiprofen (Ansaid®)
• ibuprofen (Advil®, Motrin®)
• indomethacin (Indocin®)
• ketorolac (Toradol®)
• mefenamic acid (Ponstel®)
• meloxicam (Mobic®)
• nabumetone (Relafen®)
• naproxen (Aleve®, Naprosyn®)
• piroxicam (Feldene®), and others

If you are using any of these drugs, you may not be able to use ketoprofen or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect ketoprofen. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.